Dynacortin is a novel actin bundling protein that localizes to dynamic actin structures.

  title={Dynacortin is a novel actin bundling protein that localizes to dynamic actin structures.},
  author={Douglas N. Robinson and Stephani S Ocon and Ronald S. Rock and James A Spudich},
  journal={The Journal of biological chemistry},
  volume={277 11},
Dynacortin is a novel protein that was discovered in a genetic suppressor screen of a Dictyostelium discoideum cytokinesis-deficient mutant cell line devoid of the cleavage furrow actin bundling protein, cortexillin I. While dynacortin is highly enriched in the cortex, particularly in cell-surface protrusions, it is excluded from the cleavage furrow cortex during cytokinesis. Here, we describe the biochemical characterization of this new protein. Purified dynacortin is an 80-kDa dimer with a… CONTINUE READING


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