Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish.

@article{Shi2019DydrogesteroneAT,
  title={Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish.},
  author={Wen-jun Shi and Yu-Xia Jiang and Dong-Dong Ma and Guo-Yong Huang and Lingtian Xie and Hong-xing Chen and Ming-Zhi Huang and Guang-Guo Ying},
  journal={Ecotoxicology and environmental safety},
  year={2019},
  volume={183},
  pages={
          109556
        }
}
Dydrogesterone (DDG) is a synthetic progestin used in contraception and hormone replacement therapy. Our previous transcriptome data showed that the response to light stimulus, photoperiodism and rhythm related gene ontology (GO) terms were significantly enriched in the brain of zebrafish after chronic exposure to DDG. Here we investigated the effects of DDG on the eye of zebrafish. Zebrafish were exposed to DDG at three concentration levels (3.39, 33.1, and 329 ng L-1) for 120 days. Based on… Expand
8 Citations
Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish.
TLDR
It is suggested that MPA pose a risk to fitness and survival of zebrafish in areas where MPA contamination exists, resulting in overgrowth of the eyes and interference of the eye functions. Expand
Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos
TLDR
The results indicated that DDG had potential effects on the innate immune and coagulation cascade functions in the early life zebrafish, thus further affecting fish growth and health. Expand
Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans.
TLDR
The current state of knowledge on circadian disrupters in fish is summarized, their risks to fish and knowledge gaps in animals and humans are identified. Expand
Phenotypic and transcriptomic consequences in zebrafish early-life stages following exposure to crude oil and chemical dispersant at sublethal concentrations.
TLDR
Functional enrichment analysis revealed that LEWAF and CEWAF exposure caused significant perturbations in the pathways associated with phototransduction, retinol metabolism, metabolism of xenobiotics by cytochrome P450, and immune response-related pathways that provide further mechanistic insights into the effects of crude oil and chemical dispersant on fish ELS. Expand
Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex.
TLDR
Investigation of the effects of the synthetic progestins gestodene, and drospirenone on sex differentiation in common carp by histological analysis showed increased incidence of intersex, which most probably was induced by a combination of multiple modes of action of the studied substances. Expand
Transcriptome analysis of differential gene expression in the longissimus dorsi muscle from Debao and landrace pigs based on RNA-sequencing
Abstract RNA-seq analysis was used to identify differentially expressed genes (DEGs) at the genetic level in the longissimus dorsi muscle from two pigs to investigate the genetic mechanismsExpand
Occurrence and distribution of natural and synthetic progestins, androgens, and estrogens in soils from agricultural production areas in China.
TLDR
The occurrence of biologically potent sex hormones in agricultural soils is of growing concern due to their ability to disrupt the endocrine systems of aquatic organisms after being transported to surface waters via runoff, and the importance of designing an optimal manure fertilization strategy in order to mitigate the risks posed to agroecosystems is highlighted. Expand
Zebrafish as an Animal Model for Ocular Toxicity Testing: A Review of Ocular Anatomy and Functional Assays
TLDR
The comparative anatomy of the zebrafish eye is described, the notable differences from the mammalian eye are described, and practical applications of this underutilized model for assessment of ocular toxicity are presented. Expand

References

SHOWING 1-10 OF 63 REFERENCES
Progestins alter photo-transduction cascade and circadian rhythm network in eyes of zebrafish (Danio rerio)
TLDR
It is reported that progesterone (P4) and drospirenone (DRS) interfere with the photo-transduction cascade and circadian rhythm network in the eyes of zebrafish, and the results suggest that photo- Transduction signals and circadian Rhythm are potential targets for progestins. Expand
Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio).
TLDR
The results of this study suggest that DDG has potential endocrine disrupting effects and affects the ovarian development in zebrafish. Expand
The Light Responsive Transcriptome of the Zebrafish: Function and Regulation
TLDR
Light induced gene transcription in the zebrafish is characterized at several organizational levels and Morpholino-mediated knock-down studies of two homologues of the D-box binding factor Tef indicate that these are differentially involved in the cell autonomous light induction in a gene-specific manner. Expand
MULTIPLE PAR AND E4BP4 bZIP TRANSCRIPTION FACTORS IN ZEBRAFISH: DIVERSE SPATIAL AND TEMPORAL EXPRESSION PATTERNS
TLDR
This study lays the foundation for further research regarding the involvement and specific roles of PAR and E4BP4 transcription factors in the vertebrate circadian clock mechanism. Expand
Transcriptional and Biochemical Alterations in Zebrafish Eleuthero-Embryos (Danio rerio) After Exposure to Synthetic Progestogen Dydrogesterone
TLDR
Investigation of the effects of DDG on the transcriptional and biochemical alterations in zebrafish eleuthero-embryos suggests that DDG exposure could have potential multiple effects in fish. Expand
Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio).
TLDR
Global gene expression profiles of ovary and brain of female zebrafish were characterized after exposure to 55, 553, and 5442 ng/L DRS for 14 days and multivariate analysis indicated tissue-, dose-, and treatment-dependent expression profiles. Expand
Circadian control by the reduction/oxidation pathway: Catalase represses light-dependent clock gene expression in the zebrafish
TLDR
It is shown that light induces the production of hydrogen peroxide (H2O2) that acts as the second messenger coupling photoreception to the zebrafish circadian clock, providing an attractive link between the regulation of the cellular reduction/oxidation (redox) state and the photic signaling pathways implicated in circadian control. Expand
Light signaling to the zebrafish circadian clock by Cryptochrome 1a
TLDR
It is shown that Cryptochrome 1a (Cry1a) plays a key role in light entrainment of the zebrafish clock, leading not only to entrainedment, but also to the establishment of a high-amplitude rhythm and even stopping of the clock under long photoperiods. Expand
Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function
Retinal development in vertebrates relies extensively on thyroid hormones. Their local availability is tightly controlled by several regulators, including deiodinases (Ds). Here we used morpholinoExpand
Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure.
Synthetic sex steroids, like the synthetic progestin norethindrone (NET), can affect a wide variety of biological processes via highly conserved mechanisms. NET is prevalent in surface waters, yetExpand
...
1
2
3
4
5
...