Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish.

  title={Dydrogesterone affects the transcription of genes in visual cycle and circadian rhythm network in the eye of zebrafish.},
  author={Wen-jun Shi and Yu-Xia Jiang and Dong-Dong Ma and Guo-Yong Huang and Lingtian Xie and Hong-xing Chen and Ming-Zhi Huang and Guang-Guo Ying},
  journal={Ecotoxicology and environmental safety},
Dydrogesterone (DDG) is a synthetic progestin used in contraception and hormone replacement therapy. Our previous transcriptome data showed that the response to light stimulus, photoperiodism and rhythm related gene ontology (GO) terms were significantly enriched in the brain of zebrafish after chronic exposure to DDG. Here we investigated the effects of DDG on the eye of zebrafish. Zebrafish were exposed to DDG at three concentration levels (3.39, 33.1, and 329 ng L-1) for 120 days. Based on… Expand
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