Dwarfism in Alaskan malamutes: a disease resembling metaphyseal dysplasia in human beings.

@article{Sande1982DwarfismIA,
  title={Dwarfism in Alaskan malamutes: a disease resembling metaphyseal dysplasia in human beings.},
  author={Ronald D. Sande and Joseph E Alexander and G. R. Spencer and George A. Padgett and William C. Davis},
  journal={The American journal of pathology},
  year={1982},
  volume={106 2},
  pages={224-36}
}
In a study of 300 Alaskan Malamutes, dwarfism was shown to be an autosomal recessive inherited disease with complete penetrance that resulted in disturbed endochondral bone formation. Osseous growth disturbance was manifest at the metaphyses of tubular bones. Clinical and radiographic changes were very similar to those of rickets, although appositional bone… CONTINUE READING