Dvl2-Dependent Activation of Daam1 and RhoA Regulates Wnt5a-Induced Breast Cancer Cell Migration

Abstract

BACKGROUND The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis. However, Wnt5a signaling in breast cancer progression remains poorly defined. METHODOLOGY/PRINCIPAL FINDINGS We showed here that Wnt5a activated Dvl2, Daam1 and… (More)
DOI: 10.1371/journal.pone.0037823

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