Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model.

@article{Meunier2007DutyCD,
  title={Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model.},
  author={Jason M. Meunier and Christy K. Holland and Christopher J Lindsell and George J. Shaw},
  journal={Ultrasound in medicine & biology},
  year={2007},
  volume={33 4},
  pages={
          576-83
        }
}
Combined ultrasound and tissue plasminogen activator (rt-PA) therapy, or ultrasound enhanced thrombolysis (UET), has been shown to improve recanalization in patients with acute ischemic stroke. We measured the effect of ultrasound duty cycle on the lytic efficacy of 120 kHz UET in an in vitro human clot model. The hypothesis was that an increase in duty cycle increases rt-PA lytic efficacy. Human whole blood clots were exposed to 120-kHz ultrasound and rt-PA for 30 min in human plasma. The duty… CONTINUE READING
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Review of Protocols Used in Ultrasound Thrombolysis.

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