Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage.

@article{Ng2009DutyCO,
  title={Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage.},
  author={Kenneth W. Ng and Robert L Mauck and Christopher C. B. Wang and Terri-Ann N. Kelly and Mandy M. Y. Ho and Faye Hui Chen and Gerard A. Ateshian and Clark Tung-Hui Hung},
  journal={Cellular and molecular bioengineering},
  year={2009},
  volume={2 3},
  pages={386-394}
}
This study examines how variations in the duty cycle (the duration of applied loading) of deformational loading can influence the mechanical properties of tissue engineered cartilage constructs over one month in bioreactor culture. Dynamic loading was carried out with three different duty cycles: 1 h on/1 h off for a total of 3 h loading/day, 3 h continuous loading, or 6 h of continuous loading per day, with all loading performed 5 days/week. All loaded groups showed significant increases in… CONTINUE READING

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