Dust mite-induced asthma in cynomolgus monkeys.

@article{Scott2004DustMA,
  title={Dust mite-induced asthma in cynomolgus monkeys.},
  author={Michael R. Van Scott and Jerry L Hooker and David C Ehrmann and Yoshimi Shibata and Cynthia A. Kukoly and Kenneth J. Salleng and Greg C Westergaard and Anthony Sandrasagra and Jonathan D Nyce},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 4},
  pages={1433-44}
}
Animal models exhibiting high homology with humans at the genetic and pathophysiological levels will facilitate identification and validation of gene targets underlying asthma. In the present study, a nonhuman primate model of allergic asthma was developed by sensitizing cynomolgus monkeys to dust mite antigen. Sensitization elevated allergen-specific serum IgE and IgG levels, and peripheral blood mononuclear cells isolated from sensitized animals released IL-4, IL-5, and IL-10, but not IFN… CONTINUE READING
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The definition of asthma: its relationship to other chronic obstructive lung diseases

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