During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.

@article{Melder1996DuringAV,
  title={During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.},
  author={Robert J. Melder and Gerald C. Koenig and Brian P. Witwer and Nina Safabakhsh and Lance L. Munn and Rakesh K. Jain},
  journal={Nature medicine},
  year={1996},
  volume={2 9},
  pages={992-7}
}
Localization of activated natural killer (A-NK) cells in the microvasculature of growing tumors is the result of recognition of the intracellular and vascular cell-adhesion molecules ICAM-1 and VCAM-1 on the tumor endothelium, mediated by lymphocyte function-associated protein LFA-1 and vascular lymphocyte function-associated protein VLA-4. In vitro and in vivo studies of A-NK cell adhesion to endothelial cells showed that vascular endothelial growth factor (VEGF) promotes adhesion, whereas… CONTINUE READING
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