Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis
@article{Penttil2014DurationOU, title={Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis}, author={Matti Penttil{\"a} and Erika J{\"a}{\"a}skel{\"a}inen and Noora Hirvonen and Matti Isohanni and Jouko Miettunen}, journal={British Journal of Psychiatry}, year={2014}, volume={205}, pages={88 - 94} }
Background Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. Aims To analyse the associations between DUP and long-term outcomes of schizophrenia. Method A systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta…
480 Citations
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There may not be a generalised association between DUP and neurocognition, however, specific cognitive functions may be associated with longer DUP or delayed help-seeking.
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The importance of reducing DUPrS to decrease future functional impairment in populations at risk for psychosis is highlighted, and a significant correlation between GAF scores and DUPrs was observed in the non-converter group, but not in the converters.
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