Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis

@article{Penttil2014DurationOU,
  title={Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis},
  author={Matti Penttil{\"a} and Erika J{\"a}{\"a}skel{\"a}inen and Noora Hirvonen and Matti Isohanni and Jouko Miettunen},
  journal={British Journal of Psychiatry},
  year={2014},
  volume={205},
  pages={88 - 94}
}
Background Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. Aims To analyse the associations between DUP and long-term outcomes of schizophrenia. Method A systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta… 

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis

There may not be a generalised association between DUP and neurocognition, however, specific cognitive functions may be associated with longer DUP or delayed help-seeking.

Predictors of outcome in early-onset psychosis: a systematic review

EOP patients with poorer premorbid adjustment and prominent negative symptoms at initial presentation are at risk of poor outcome and should be the target of careful monitoring and more intensive interventions to address whether the disease course can be modified in this especially severely affected group.

The clinical significance of duration of untreated psychosis: an umbrella review and random‐effects meta‐analysis

It is concluded that DUP is an important prognostic factor at first presentation and predicts clinically relevant outcomes over the course of illness in patients with schizophrenia spectrum disorders and affective and non‐affective psychosis.

Duration of untreated illness as a key to early intervention in schizophrenia: A review

Relationship between duration of untreated prodromal symptoms and symptomatic and functional recovery

The importance of reducing DUPrS to decrease future functional impairment in populations at risk for psychosis is highlighted, and a significant correlation between GAF scores and DUPrs was observed in the non-converter group, but not in the converters.
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