Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis

  title={Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis},
  author={Matti Penttil{\"a} and Erika J{\"a}{\"a}skel{\"a}inen and Noora Hirvonen and Matti Isohanni and Jouko Miettunen},
  journal={British Journal of Psychiatry},
  pages={88 - 94}
Background Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. Aims To analyse the associations between DUP and long-term outcomes of schizophrenia. Method A systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta… 

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis

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EOP patients with poorer premorbid adjustment and prominent negative symptoms at initial presentation are at risk of poor outcome and should be the target of careful monitoring and more intensive interventions to address whether the disease course can be modified in this especially severely affected group.

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It is concluded that DUP is an important prognostic factor at first presentation and predicts clinically relevant outcomes over the course of illness in patients with schizophrenia spectrum disorders and affective and non‐affective psychosis.

Duration of untreated illness as a key to early intervention in schizophrenia: A review

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Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review.

There is convincing evidence of a modest association between DUP and outcome, which supports the case for clinical trials that examine the effect of reducing DUP.

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Poor pre-morbid functioning, baseline symptoms, DUP and neurological soft signs at onset independently predict poor long-term outcome in first-episode psychosis.

Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.

Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes.

A systematic review of longitudinal outcome studies of first-episode psychosis

Outcome from FEP may be more favorable than previously reported, and treatment and methodological variables may be important contributors to outcome, and a multi-dimensional, globally used definition of outcome is required.

Predictors of Remission and Recovery in a First-Episode Schizophrenia Spectrum Disorder Sample: 2-Year Follow-up of the OPUS Trial

Predictors of good outcome for patients with first-episode schizophrenia spectrum disorder should be focused on potentially malleable predictors of outcome, for example, reducing DUP and paying special attention to patients who are unlikely to achieve good outcome.