Duration of untreated psychosis: impact on 2-year outcome

@article{Addington2004DurationOU,
  title={Duration of untreated psychosis: impact on 2-year outcome},
  author={Jean M. Addington and Sarah van Mastrigt and Donald Addington},
  journal={Psychological Medicine},
  year={2004},
  volume={34},
  pages={277 - 284}
}
Background. The duration of untreated psychosis has been postulated to be a predictor of clinical outcome in schizophrenia. Although several prospective studies support the relationship, some studies do not. These differences may be due to a number of methodological issues. The objectives of this study are: (i) to address many of the methodological limitations of earlier studies such as variations in sample size and selection, type of treatment provided, differences in measurement of DUP and… 
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75 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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75 Citations

Duration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis
Predictors of 10-year outcome of first-episode psychosis
TLDR
Poor pre-morbid functioning, baseline symptoms, DUP and neurological soft signs at onset independently predict poor long-term outcome in first-episode psychosis.
Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study.
TLDR
Findings suggest that DUP is influenced both by aspects of the early clinical course and by the social context, with an insidious mode of onset associated with a substantially longer DUP compared with an acute onset.
Association between duration of untreated psychosis and executive function in early-onset psychosis
Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia
TLDR
The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.
Outcome measures in early psychosis
  • S. Singh
  • Medicine, Psychology
    British Journal of Psychiatry
  • 2007
TLDR
The evolution of the concept of DUP is explored, the evidence for its predictive value is synthesised, the problems in measurement are highlighted, and the potential pitfalls are considered.
First-episode psychosis: psychopathology, quality of life, and functional outcome.
TLDR
The findings from longitudinal studies of the dimensional psychopathology of first-episode psychosis suggest continuity of some psychopathological dimensions from premorbid through prodromal to post-onset phases of psychosis and some aspects of longer-term course.
follow-up study of first-episode schizophrenia Duration of untreated psychosis and social function: 1-year
TLDR
It is revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation, underline the importance of taking account of the phenomenological overlap between measures.
Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.
TLDR
Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes.
Family context and duration of untreated psychosis (DUP): Results from the Sao Paulo Study
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References

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TLDR
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Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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