Duration of untreated psychosis: impact on 2-year outcome

  title={Duration of untreated psychosis: impact on 2-year outcome},
  author={Jean M. Addington and Sarah van Mastrigt and Donald Addington},
  journal={Psychological Medicine},
  pages={277 - 284}
Background. The duration of untreated psychosis has been postulated to be a predictor of clinical outcome in schizophrenia. Although several prospective studies support the relationship, some studies do not. These differences may be due to a number of methodological issues. The objectives of this study are: (i) to address many of the methodological limitations of earlier studies such as variations in sample size and selection, type of treatment provided, differences in measurement of DUP and… 
Duration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis
Predictors of 10-year outcome of first-episode psychosis
Poor pre-morbid functioning, baseline symptoms, DUP and neurological soft signs at onset independently predict poor long-term outcome in first-episode psychosis.
Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study.
Findings suggest that DUP is influenced both by aspects of the early clinical course and by the social context, with an insidious mode of onset associated with a substantially longer DUP compared with an acute onset.
Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia
The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.
Outcome measures in early psychosis
  • S. Singh
  • Medicine, Psychology
    British Journal of Psychiatry
  • 2007
The evolution of the concept of DUP is explored, the evidence for its predictive value is synthesised, the problems in measurement are highlighted, and the potential pitfalls are considered.
First-episode psychosis: psychopathology, quality of life, and functional outcome.
The findings from longitudinal studies of the dimensional psychopathology of first-episode psychosis suggest continuity of some psychopathological dimensions from premorbid through prodromal to post-onset phases of psychosis and some aspects of longer-term course.
follow-up study of first-episode schizophrenia Duration of untreated psychosis and social function: 1-year
It is revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation, underline the importance of taking account of the phenomenological overlap between measures.
Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.
Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes.


One year outcome in first episode psychosis: influence of DUP and other predictors
Duration of untreated psychosis and cognitive functioning in first-episode patients
Findings do not provide support for a toxic effect of DUP on cognitive functioning, and other mechanisms through which DUP might affect outcome such as psychological engulfment, social support and adherence to medication are discussed.
Causes and consequences of duration of untreated psychosis in schizophrenia.
Longer DUP results partly from a pattern of symptoms and social functioning which reduces concern by the sufferer and relevant others, and has implications for targeting early intervention.
Does treatment delay in first-episode psychosis really matter?
DUP consistently predicts outcome independently of other variables, and is not simply a proxy for other factors, which means it could prove to be a target for secondary preventive efforts in early psychosis.
Duration of untreated psychosis: a critical examination of the concept and its importance
Evidence thus far suggests that DUP may be related to ease of reducing psychotic symptoms once treatment begins for first episode patients, but there is no evidence of a relationship to likelihood of relapse.
West London first-episode study of schizophrenia. Clinical correlates of duration of untreated psychosis.
There was little evidence of any association between either DUP or DUI and progressive deterioration in the schizophrenic illness or the development of resistance to initial drug treatment.
Duration of untreated psychosis predicts treatment outcome in an early psychosis program
First-episode schizophrenia: I. Early course parameters.
Early course parameters of a Norwegian first-episode sample demonstrated strong gender differences, with male patients having significantly higher frequency of single marital status, lower educational status, schizophrenia, early age at onset, and lower Global Assessment of Functioning scores the last year before hospitalization.
Untreated initial psychosis: its relation to quality of life and symptom remission in first-episode schizophrenia.
Investigation of the relationship between untreated initial psychosis duration and quality of life, symptom severity, and time to remission of positive symptoms in neuroleptic-naive patients with DSM-IV schizophrenia found that earlier age at illness onset was associated with longer duration of untreated prodromal psychotic symptoms.