Duration of rapamycin treatment has differential effects on metabolism in mice.

@article{Fang2013DurationOR,
  title={Duration of rapamycin treatment has differential effects on metabolism in mice.},
  author={Yimin Fang and R. Niccole Westbrook and Cristal Monique Hill and Ravneet Kaur Boparai and Oge Arum and Adam Spong and Feiya Wang and Martin A. Javors and Jie Chen and Liou Y Sun and Andrzej Bartke},
  journal={Cell metabolism},
  year={2013},
  volume={17 3},
  pages={456-62}
}
The evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism, and aging. In the first robust demonstration of pharmacologically-induced life extension in mammals, longevity was extended in mice treated with rapamycin, an inhibitor of mechanistic TOR (mTOR). However, detrimental metabolic effects of rapamycin treatment were also reported, presenting a paradox of improved survival despite metabolic impairment. How rapamycin extended lifespan in mice with such… CONTINUE READING