Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin
@article{Lilja2000DurationOE, title={Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin}, author={Jari J. Lilja and Kari T. Kivistö and Pertti J. Neuvonen}, journal={Clinical Pharmacology \& Therapeutics}, year={2000}, volume={68} }
Grapefruit juice is a potent inhibitor of CYP3A4‐mediated drug metabolism. We wanted to investigate how long the inhibitory effect of grapefruit juice lasts, with the CYP3A4 substrate simvastatin used as a model drug.
178 Citations
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