Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin

@article{Lilja2000DurationOE,
  title={Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin},
  author={J. Lilja and K. Kivistö and P. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2000},
  volume={68}
}
Grapefruit juice is a potent inhibitor of CYP3A4‐mediated drug metabolism. We wanted to investigate how long the inhibitory effect of grapefruit juice lasts, with the CYP3A4 substrate simvastatin used as a model drug. 
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