Duration of beta-blockade with metoprolol and atenolol: influence of drug oxidation.

Abstract

The beta-blocking activity of two slow-release formulations of metoprolol was compared to conventional metoprolol and atenolol which were each given once daily for one week to 8 healthy volunteers in a balanced crossover study. Plasma levels of metoprolol were also measured. Only metoprolol SA (Astra) produced plasma concentrations significantly higher than… (More)

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