Duration of adrenal inhibition following a single dose of etomidate in critically ill patients

@article{Vinclair2007DurationOA,
  title={Duration of adrenal inhibition following a single dose of etomidate in critically ill patients},
  author={Marc Vinclair and Christophe Broux and Patrice Faure and Julien Brun and Celine Genty and Claude Jacquot and Olivier Chabre and Jean-François Payen},
  journal={Intensive Care Medicine},
  year={2007},
  volume={34},
  pages={714-719}
}
ObjectiveTo determine the incidence and duration of adrenal inhibition induced by a single dose of etomidate in critically ill patients.DesignProspective, observational cohort study.SettingThree intensive care units in a university hospital.PatientsForty critically ill patients without sepsis who received a single dose of etomidate for facilitating endotracheal intubation.Measurements and main resultsSerial serum cortisol and 11β-deoxycortisol samples were taken at baseline and 60 min after… 
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TLDR
Etomidate use for induction of anesthesia during RSI was associated with clinically significant hypotension when compared to other sedatives, and the hypotension was transient and did not translate into statistically significant differences in the secondary clinical endpoints.
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TLDR
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TLDR
A single dose of etomidate may attenuate stimulated more than basal cortisol synthesis, however, it may only partly contribute, particularly in the stressed sepsis patient, to the adrenal dysfunction of CIRCI, in addition to substrate deficiency.
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TLDR
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Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients.
TLDR
No strong evidence exists that etomidate increases mortality in critically ill patients when compared to other bolus dose induction agents, and single (bolus) dose Etomidate for emergency airway intervention compared to any other rapid-acting intravenous bolus single-dose induction agent.
The effect of etomidate on adrenal function in critical illness: a systematic review
TLDR
There is an increased rate of AI and mortality in critically ill patients who received etomidate and non-etomidate anesthesia, and this results in an increased risk ratio (RR) for AI.
The Effects of Single-Dose Etomidate Versus Propofol on Cortisol Levels in Pediatric Patients Undergoing Urologic Surgery: A Randomized Controlled Trial
TLDR
Compared with propofol, a single induction dose of etomidate suppressed postoperative cortisol levels in healthy children undergoing urologic surgery and was not associated with any changes in clinical outcomes.
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