Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

@article{Chen2001DurationON,
  title={Duration of Nuclear NF-$\kappa$B Action Regulated by Reversible Acetylation},
  author={Lin-Feng Chen and Wolfgang Fischle and Eric Verdin and Warner C. Greene},
  journal={Science},
  year={2001},
  volume={293},
  pages={1653 - 1657}
}
The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which normally bind and sequester this pleiotropically active factor in the cytoplasm. The subsequent molecular events that regulate the termination of nuclear NF-κB action remain poorly defined, although the activation of de novo IκBα gene expression by NF-κB likely plays a key role. Our studies now demonstrate that the RelA… 
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