Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma.

@article{Kraunz2006DurationBN,
  title={Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma.},
  author={Kim S Kraunz and Michael D Mcclean and Heather H. Nelson and Edward Peters and Henry Calderon and Karl T. Kelsey},
  journal={Cancer research},
  year={2006},
  volume={66 8},
  pages={4512-5}
}
In tobacco-associated solid tumors, evidence suggests that the pattern of carcinogen exposure is related to the nature of somatic gene inactivation within crucial pathways, including the retinoblastoma (Rb) pathway. One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly observed in head and neck squamous cell carcinoma… CONTINUE READING