Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers.

@article{Hawkins1990DurationAS,
  title={Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers.},
  author={Clive Paul Hawkins and Patrick M. Munro and Fiona C Mackenzie and J W Kesselring and Paul S. Tofts and E P du Boulay and D. Landon and W. Ian McDonald},
  journal={Brain : a journal of neurology},
  year={1990},
  volume={113 ( Pt 2)},
  pages={365-78}
}
Gadolinium-DTPA (Gd-DTPA) enhancement seen with magnetic resonance imaging in chronic relapsing experimental allergic encephalomyelitis (CREAE) corresponded with sites of blood-brain barrier breakdown judged by traditional markers in areas of inflammatory demyelination. Duration of Gd-DTPA leakage for individual lesions in CREAE varied from 5 days to more than 5 wks. By contrast, in acute EAE leakage was of shorter duration (always less than 5 days). Selective enhancement was observed in CREAE… CONTINUE READING