Duration and fitness dependence of quasispecies memory.

  title={Duration and fitness dependence of quasispecies memory.},
  author={CARMEN M. RUIZ-JARABO and Armando Arias and Carmen Molina-Par{\'i}s and Carlos Briones and Eric Baranowski and Cristina Escarm{\'i}s and Esteban Domingo},
  journal={Journal of molecular biology},
  volume={315 3},
The duration and fitness dependence of memory in viral quasispecies evolving in cell culture have been investigated using two genetic markers of foot-and-mouth disease virus (FMDV). In lineages of antigenic variant FMDV RED, which reverted to FMDV RGD, memory FMDV RED genomes were detected after 50 infectious cycles, and memory level was fitness dependent. In growth-competition experiments between a reference FMDV RGD and two different FMDV RED populations, a 7.6-fold higher fitness of the… CONTINUE READING