Duration, combination and timing: the signal integration model of dendritic cell activation.

@article{Macagno2007DurationCA,
  title={Duration, combination and timing: the signal integration model of dendritic cell activation.},
  author={Annalisa Macagno and Giorgio Napolitani and Antonio Lanzavecchia and Federica Sallusto},
  journal={Trends in immunology},
  year={2007},
  volume={28 5},
  pages={227-33}
}
The activation of resting dendritic cells (DCs) is a crucial step in the initiation of adaptive immunity because it links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. It is well recognized that a wide variety of microbial products and endogenous… CONTINUE READING