Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.

@article{Goepfert2007DurableHA,
  title={Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.},
  author={Paul A Goepfert and Georgia D. Tomaras and Helen Horton and David C. Montefiori and Guido Ferrari and Mark Deers and Gerald Hermann Voss and Marguerite Christine Koutsoukos and Louise Pedneault and Pierre G Vandepapeli{\`e}re and M Juliana McElrath and Paul Spearman and Jonathan D. Fuchs and Beryl A Koblin and William A. Blattner and Sharon E. Frey and Lindsey Robert Baden and Clayton D. Harro and Thomas Andrew Evans},
  journal={Vaccine},
  year={2007},
  volume={25 3},
  pages={
          510-8
        }
}
BACKGROUND Use of the recombinant proteins NefTat and gp120(W61D) formulated with the AS02A adjuvant system was previously shown to protect against AIDS in a rhesus macaque SHIV animal model system. METHODS Eighty-four HIV uninfected human participants were vaccinated intramuscularly at 0, 1, and 3 months and evaluated for safety. Immune responses were analyzed for the presence of vaccine-induced antibody and T lymphocyte responses. RESULTS The vaccines were safe and well tolerated at all… CONTINUE READING
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