Dupuytren's contracture is associated with sprouting of substance P positive nerve fibres and infiltration by mast cells.

@article{Schubert2006DupuytrensCI,
  title={Dupuytren's contracture is associated with sprouting of substance P positive nerve fibres and infiltration by mast cells.},
  author={Thomas E O Schubert and Claudia Weidler and Nicola Borisch and C A Schubert and Ferdinand Hofstaedter and Rainer H Straub},
  journal={Annals of the rheumatic diseases},
  year={2006},
  volume={65 3},
  pages={414-5}
}
D upuytren’s contracture is a benign proliferative disease of connective tissue. It is characterised by an abnormal fibroblast proliferation and matrix deposition affecting the palmar fascia. There is evidence of genetic predisposition, but the precise cause remains unclear. Inflammatory infiltration of palmar tissue from Dupuytren’s contracture has been reported by several authors, who concluded that Dupuytren’s contracture may be a chronic inflammatory disease. To support the inflammatory… CONTINUE READING