Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets

  title={Duplications in RB1CC1 are associated with schizophrenia; identification in large
European sample sets},
  author={Franziska Degenhardt and Lutz Priebe and Stuart Meier and Leonhard Lennertz and Frank Streit and Stephanie H. Witt and Andrea Hofmann and Tim Becker and Rainald Moessner and Wolfang Maier and Igor Nenadic and Heinrich Sauer and Manuel Mattheisen and Jacobine E. Buizer-Voskamp and Roel A. Ophoff and Dan Rujescu and Ina Giegling and Andr{\'e}s Ingason and Melanie Wagner and Bruno Delobel and Joris Andrieux and Andreas Meyer-Lindenberg and Andeas Heinz and Hildrun Walter and Susanne Moebus and Aidan Corvin and Marcela Rietschel and Markus M. N{\"o}then and Sven Cichon and Ren{\'e} S. Kahn and Don H. Linszen and Jim van Os and Durk Wiersma and Richard Bruggeman and Wiepke Cahn and Lieuwe de Haan and Lydia Krabbendam and Inez Myin-Germeys},
  booktitle={Translational Psychiatry},
Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested to contribute to the risk of developing SCZ. Although these studies show an overall excess of de novo mutations among patients compared with controls, it is not easy to pinpoint specific genes hit by de novo mutations as actually involved in the disease process. Importantly… CONTINUE READING
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Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2012