Duplication of the Yeast Spindle Pole Body Once per Cell Cycle.

@article{Rthnick2016DuplicationOT,
  title={Duplication of the Yeast Spindle Pole Body Once per Cell Cycle.},
  author={Diana R{\"u}thnick and Elmar Schiebel},
  journal={Molecular and cellular biology},
  year={2016},
  volume={36 9},
  pages={
          1324-31
        }
}
The yeast spindle pole body (SPB) is the functional equivalent of the mammalian centrosome. Centrosomes and SPBs duplicate exactly once per cell cycle by mechanisms that use the mother structure as a platform for the assembly of the daughter. The conserved Sfi1 and centrin proteins are essential components of the SPB duplication process. Sfi1 is an elongated molecule that has, in its center, 20 to 23 binding sites for the Ca(2+)-binding protein centrin. In the yeastSaccharomyces cerevisiae, all… CONTINUE READING
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