Duplication of partial spinosyn biosynthetic gene cluster in Saccharopolyspora spinosa enhances spinosyn production.

@article{Tang2011DuplicationOP,
  title={Duplication of partial spinosyn biosynthetic gene cluster in Saccharopolyspora spinosa enhances spinosyn production.},
  author={Ying Tang and Liqiu Xia and Xuezhi Ding and Yushuang Luo and Fan Yen Huang and Yuanwei Jiang},
  journal={FEMS microbiology letters},
  year={2011},
  volume={325 1},
  pages={22-9}
}
Spinosyns, the secondary metabolites produced by Saccharopolyspora spinosa, are the active ingredients in a family of insect control agents. Most of the S. spinosa genes involved in spinosyn biosynthesis are found in a contiguous c. 74-kb cluster. To increase the spinosyn production through overexpression of their biosynthetic genes, part of its gene cluster (c. 18 kb) participating in the conversion of the cyclized polyketide to spinosyn was obtained by direct cloning via Red/ET recombination… CONTINUE READING

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