Duplication of chromosome arms 9q and 11q: evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma.

@article{Liebisch2005DuplicationOC,
  title={Duplication of chromosome arms 9q and 11q: evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma.},
  author={Peter Liebisch and Daniel Scheck and Seiichi Alvise Ern{\'e} and Alexander Wellmann and Christiane Wendl and Sibylle Janczik and Sonja Kolmus and Alexander Kroeber and Hermann Einsele and Christian Straka and Hartmut Goldschmidt and Axel Benner and Stephan Stilgenbauer and Hartmut D{\"o}hner},
  journal={Genes, chromosomes & cancer},
  year={2005},
  volume={42 1},
  pages={
          78-81
        }
}
14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a series of 108 MM patients using fluorescence in situ hybridization and DNA probes mapping to chromosome bands 1q21, 9q34, 11q25, 13q14, and 14q32. Three subsets of tumors were defined: (1) MM… CONTINUE READING
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