Duplication of an amphioxus myogenic bHLH gene is independent of vertebrate myogenic bHLH gene duplication.

@article{Araki1996DuplicationOA,
  title={Duplication of an amphioxus myogenic bHLH gene is independent of vertebrate myogenic bHLH gene duplication.},
  author={Isato Araki and Kouzou Terazawa and Noriyuki Satoh},
  journal={Gene},
  year={1996},
  volume={171 2},
  pages={231-6}
}
Gene duplication is thought to be a major genetic change that may have permitted the evolution of vertebrates from invertebrates. The myogenic genes encode basic helix-loop-helix (bHLH) transcriptional factors essential for the formation of skeletal muscle. The invertebrate genome contains only a single myogenic bHLH gene, whereas the vertebrate genome contains four (MyoD, Myf-5, myogenin and MRF4). Since the tunicate genome contains a single myogenic bHLH gene, its duplication might have… CONTINUE READING

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