Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux

  title={Duodenogastric reflux potentiates the injurious effects of gastroesophageal reflux},
  author={Martin Fein and Adrian P. Ireland and Manfred P. Ritter and Jeffrey H. Peters and Jeffrey A. Hagen and Cedric G. Bremmer and Tom R. Demeester},
  journal={Journal of Gastrointestinal Surgery},
Experimental studies have shown that the severity of esophageal mucosal injury in gastroesophageal reflux disease is related to the reflux of both gastric and duodenal juice. The purpose of this study was to determine whether duodenal juice potentiates esophageal injury in patients with reflux disease or, inf act, causes no harm allowing acid and pepsin to do the damage. A total of 148 consecutive patients who had no previous gastric or esophageal surgery underwent endoscopy and biopsy… CONTINUE READING


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