Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis.

@article{Zoller1999DuodenalM,
  title={Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis.},
  author={Heinz Zoller and Antonello Pietrangelo and Wolfgang Vogel and Guenter Weiss},
  journal={Lancet},
  year={1999},
  volume={353 9170},
  pages={2120-3}
}
BACKGROUND Although the gene for hereditary haemochromatosis has been cloned, the mechanism by which iron uptake is inappropriately increased in this disorder is unclear. Iron absorption is regulated by the duodenal metal transporter, DMT-1, also called NRAMP-2. We investigated the expression of NRAMP-2 in patients with hereditary haemochromatosis. METHODS Duodenal biopsy samples were taken from 20 patients with haemochromatosis homozygous for the C282Y mutation and from ten controls. NRAMP-2… CONTINUE READING

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