Duodenal defence mechanisms: role of mucosal bicarbonate secretion


The duodenal epithelium secretes bicarbonate at higher rates than does the stomach (or more distal small intestine) and the duodenal secretion is currently accepted as the most important defence mechanism against acid discharged from the stomach. HCO3 - entering the continuous layer of visco-elastic mucus gel on top of the epithelial surface maintains pH in… (More)
DOI: 10.1163/156856002321544792