Duodenal biopsies of HIV-infected patients with diarrhoea exhibit epithelial barrier defects but no active secretion.

@article{Stockmann1998DuodenalBO,
  title={Duodenal biopsies of HIV-infected patients with diarrhoea exhibit epithelial barrier defects but no active secretion.},
  author={Martin Stockmann and Michael Fromm and Heinz Schmitz and Wolfgang Schmidt and E. O. Riecken and J{\"o}rg-Dieter Schulzke},
  journal={AIDS},
  year={1998},
  volume={12 1},
  pages={43-51}
}
OBJECTIVES To characterize diarrhoeal mechanisms in HIV-infected patients, epithelial transport and barrier function of the duodenal mucosa was investigated in vitro. PATIENTS Twenty-one HIV-seropositive patients (13 asymptomatic and eight with diarrhoea) and 12 controls from an urban referral-based tertiary care centre in Berlin who underwent duodenoscopy. METHODS A new miniaturized Ussing chamber allowed measurements on duodenal forceps biopsies. Epithelial barrier function was… CONTINUE READING

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