Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

@article{Mallinckrodt2005DuloxetineIT,
  title={Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features},
  author={Craig Mallinckrodt and John G. Watkin and Chaofeng Liu and Madelaine M. Wohlreich and Joel Raskin},
  journal={BMC Psychiatry},
  year={2005},
  volume={5},
  pages={1 - 1}
}
BackgroundThe most prominent feature of melancholic depression is a near-total loss of the capacity to derive pleasure from activities or other positive stimuli. Additional symptoms can include psychomotor disturbances, anorexia, excessive guilt, and early awakening from sleep. Melancholic patients may exhibit treatment responses and outcomes that differ from those of non-melancholic patients. Pooled data from double-blind, placebo-controlled studies were utilized to compare the efficacy of… CONTINUE READING

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