Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium.

@article{Smith2008DuffyAR,
  title={Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium.},
  author={Emily McCall Smith and Helen Michelle McGettrick and Michael A. Stone and John Sutherland Shaw and Alison Cartwright and Gerard B Nash and Christopher D Buckley and G Ed Rainger},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 7},
  pages={
          1968-73
        }
}
OBJECTIVE The role of chemokines and their transporters in rheumatoid arthritis (RA) is poorly described. Evidence suggests that CXCL5 plays an important role, because it is abundant in RA tissue, and its neutralization moderates joint damage in animal models of arthritis. Expression of the chemokine transporter Duffy antigen receptor for chemokines (DARC) is also up-regulated in early RA. The aim of this study was to investigate the role of CXCL5 and DARC in regulating neutrophil recruitment… CONTINUE READING
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