Due to reverse electron transfer, mitochondrial H2O2 release increases with age in human vastus lateralis muscle although oxidative capacity is preserved.

@article{Capel2005DueTR,
  title={Due to reverse electron transfer, mitochondrial H2O2 release increases with age in human vastus lateralis muscle although oxidative capacity is preserved.},
  author={Fr{\'e}d{\'e}ric Capel and Virginie Rimbert and Delphine Lioger and Alan Diot and Paulette Rousset and Philippe Patureau Mirand and Yves Boirie and B{\'e}atrice Morio and Laurent Mosoni},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 4},
  pages={505-11}
}
Age-related changes in mitochondrial H2O2 release (MHR) could be responsible for an increase in oxidative stress in skeletal muscle and participate in the development of sarcopenia. We compared MHR in vastus lateralis biopsies obtained from young (23.5+/-2.0 year, n=6) and elderly (67.3+/-1.5 year, n=6) healthy sedentary men. Isolated mitochondria were incubated in the presence of glutamate/malate/succinate, with or without rotenone. Muscle fat oxidative capacity, citrate synthase, complex II… CONTINUE READING
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