Ducts isolated from the pancreas of CFTR-null mice secrete fluid

  title={Ducts isolated from the pancreas of CFTR-null mice secrete fluid},
  author={Patricia Pascua and M{\'o}nica Ruiz Garc{\'i}a and Magali Fern{\'a}ndez-Salazar and M. Pilar Hern{\'a}ndez-Lorenzo and Jos{\'e} Juli{\'a}n Calvo and William H Colledge and R. Maynard Case and Martin C. Steward and Jos{\'e} Ignacio San Rom{\'a}n},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
The pancreatic pathology in cystic fibrosis (CF) is normally attributed to the failure of ductal fluid secretion resulting from the lack of functional CF transmembrane conductance regulator (CFTR). However, murine models of CF show little or no pancreatic pathology. To resolve this dichotomy we analysed the transport mechanisms involved in fluid and electrolyte secretion by pancreatic ducts isolated from CFTR-null mice. Experiments were performed on cultured interlobular duct segments isolated… CONTINUE READING


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