Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution.

@article{Allred2008DuctalCI,
  title={Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution.},
  author={Donald Craig Allred and Yun Wu and Sufeng Mao and Iris Nagtegaal and Sangjun Lee and Charles M. Perou and Syed Khalid Mohsin and Peter J. O'Connell and Anna I. Tsimelzon and Dan J. Medina},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 2},
  pages={
          370-8
        }
}
PURPOSE Human invasive breast cancers (IBC) show enormous histologic and biological diversity. This study comprehensively evaluated diversity in ductal carcinoma in situ (DCIS), the immediate precursors of IBCs. EXPERIMENTAL DESIGN The extent of diversity for conventional histologic grade and standard prognostic biomarkers assessed by immunohistochemistry was evaluated in a series of pure DCIS (n = 200) compared with a contemporaneous series of IBCs (n = 200). A subset of the DCIS (n = 25… CONTINUE READING

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Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution

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