Duck hepatitis B virus nucleocapsids formed by N-terminally extended or C-terminally truncated core proteins disintegrate during viral DNA maturation.

@article{Kck1998DuckHB,
  title={Duck hepatitis B virus nucleocapsids formed by N-terminally extended or C-terminally truncated core proteins disintegrate during viral DNA maturation.},
  author={Josef K{\"o}ck and Stefan D Wieland and H. E. Blum and Fritz von Weizs{\"a}cker},
  journal={Journal of virology},
  year={1998},
  volume={72 11},
  pages={
          9116-20
        }
}
Hepadnaviruses are DNA viruses that replicate through reverse transcription of an RNA pregenome. Viral DNA synthesis takes place inside viral nucleocapsids, formed by core protein dimers. Previous studies have identified carboxy-terminal truncations of the core protein that affect viral DNA maturation. Here, we describe the effect of small amino-terminal insertions into the duck hepatitis B virus (DHBV) core protein on viral DNA replication. All insertion mutants formed replication-competent… CONTINUE READING
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