Duchenne muscular dystrophy gene product is not identical in muscle and brain

@article{Nudel1989DuchenneMD,
  title={Duchenne muscular dystrophy gene product is not identical in muscle and brain},
  author={Uri Nudel and Dorit Zuk and Paz Einat and Elisha Zeelon and Zehava Levy and Sara Neuman and David Yaffe},
  journal={Nature},
  year={1989},
  volume={337},
  pages={76-78}
}
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder resulting in progressive degeneration of the muscle. It affects about 1 in 3,500 male children. Seeker's muscular dystrophy is a less severe disease allelic to DMD. Some 30% of DMD patients suffer from various degrees of mental retardation (see ref. 1 for review). The giant DMD gene spans about 2,000 kilobases and codes for a 14-kilobase messenger RNA and a protein of molecular weight 427,000 (ref. 2). DMD mRNA is most abundant… CONTINUE READING

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