Duchenne muscular dystrophy: alterations in lymphocyte fluidity.


We have studied lymphocyte membrane from 7 patients with Duchenne Muscular Dystrophy (DMD) and 8 normal controls using fluorescence polarization of 1,6-diphenyl-hexatriene (DPH). The microviscosity of lymphocytes membrane is significatively higher in DMD patients than in normal controls. Our results support the hypothesis of a generalized membrane defect in Duchenne Muscular Dystrophy.

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@article{Ferretti1983DuchenneMD, title={Duchenne muscular dystrophy: alterations in lymphocyte fluidity.}, author={Gianna Ferretti and A M Falcioni and Giovanna Curatola and Beatriz S Valentini and Franca Saccucci}, journal={Bollettino della Società italiana di biologia sperimentale}, year={1983}, volume={59 7}, pages={1035-40} }