Duchenne muscular dystrophy: Pathogenetic aspects and genetic prevention

@article{Moser1984DuchenneMD,
  title={Duchenne muscular dystrophy: Pathogenetic aspects and genetic prevention},
  author={Hans Moser},
  journal={Human Genetics},
  year={1984},
  volume={66},
  pages={17-40}
}
Duchenne muscular dystrophy (DMD) is the most common sex linked lethal disease in man (one case in about 4000 male live births). The patients are wheelchair bound around the age of 8–10 years and usually die before the age of 20 years. The mutation rate, estimated by different methods and from different population studies, is in the order of 7×10-5, which is higher than for any other X-linked genetic disease. Moreover, unlike other X linked diseases such as hemophilia A or Lesh-Nyhan's disease… CONTINUE READING

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