[Dubin-Johnson syndrome: molecular basis and pathogenesis].

Abstract

The Dubin-Johnson syndrome (DJS) is an autosomal recessive liver disorder characterized by a chronic conjugated hyperbilirubinemia a dark greenish appearance of liver tissue, a double peaked sulfobromophthalein clearance curve, and a characteristic lysosomal accumulation of black pigment "melanine-like" in the hepatocytes. Laboratory datas indicated an increased urinary excretion of coproporphrin isomer I and leukotriene metabolites. In an effort to understand the morphological pattern and the pathogenesis of this disease we reviewed four cases of DJS.

Cite this paper

@article{MzabiRegaya2002DubinJohnsonSM, title={[Dubin-Johnson syndrome: molecular basis and pathogenesis].}, author={Sabah Mzabi-Regaya and Aschraf Chadli-Debbiche and Ehsen Ben Brahim and Sami Gritli and Carole Goutallier-Ben Fadhel and Mohamed Tahar Khalfallah}, journal={La Tunisie médicale}, year={2002}, volume={80 4}, pages={228-32} }