Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors.

  title={Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors.},
  author={Jonathan Toma and Jeannette M. Whitcomb and Christos J. Petropoulos and Wei Huang},
  volume={24 14},
OBJECTIVE(S) Dual HIV-1 utilizes cellular CCR5 and CXCR4 coreceptors to enter host cells. Recent studies indicate that the ability of these viruses to use both coreceptors varies significantly in cell lines expressing CXCR4 or CCR5; however, it is not clear whether differences in coreceptor mediated infection in vitro reflect infection of primary cells in vivo. METHODS We evaluated coreceptor usage of dual envelope clones from patient viruses using a single-cycle pseudovirus assay conducted… CONTINUE READING

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