Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid.

@article{Lin2011DualTF,
  title={Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid.},
  author={Lan Lin and Eric D Bankaitis and Lisa Heimbach and Ning Li and Magnus {\AA}brink and Gunnar Pejler and Lijia An and Luis A Diaz and Zena Werb and Zhi Liu},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 43},
  pages={37358-67}
}
Mouse mast cell protease-4 (mMCP-4) has been linked to autoimmune and inflammatory diseases, although the exact mechanisms underlying its role in these pathological conditions remain unclear. Here, we have found that mMCP-4 is critical in a mouse model of the autoimmune skin blistering disease bullous pemphigoid (BP). Mice lacking mMCP-4 were resistant to experimental BP. Complement activation, mast cell (MC) degranulation, and the early phase of neutrophil (PMN) recruitment occurred comparably… CONTINUE READING

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