Dual targeting strategies with bispecific antibodies.

  title={Dual targeting strategies with bispecific antibodies.},
  author={Roland E Kontermann},
  volume={4 2},
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most of the marketed antibodies are monospecific and therefore capable of interacting and interfering with a single target. However, complex diseases are often multifactorial in nature, and involve redundant or synergistic action of disease mediators or upregulation of different receptors, including crosstalk between their signaling networks. Consequently, blockade of… CONTINUE READING