Dual targeting property of the N-terminal signal sequence of P4501A1. Targeting of heterologous proteins to endoplasmic reticulum and mitochondria.

@article{Bhagwat1999DualTP,
  title={Dual targeting property of the N-terminal signal sequence of P4501A1. Targeting of heterologous proteins to endoplasmic reticulum and mitochondria.},
  author={Shripad V. Bhagwat and Gopa Roy Biswas and Hindupur K. Anandatheerthavarada and Sankar Addya and William M. Pandak and Narayan G Avadhani},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 34},
  pages={
          24014-22
        }
}
Recent studies from our laboratory showed that the beta-naphthoflavone-inducible cytochrome P4501A1 is targeted to both the endoplasmic reticulum (ER) and mitochondria. In the present study, we have further investigated the ability of the N-terminal signal sequence (residues 1-44) of P4501A1 to target heterologous proteins, dihydrofolate reductase, and the mature portion of the rat P450c27 to the two subcellular compartments. In vitro transport and in vivo expression experiments show that N… CONTINUE READING
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