Dual targeting properties of the N-terminal signal sequence of Arabidopsis thaliana THI1 protein to mitochondria and chloroplasts

@article{Chabregas2001DualTP,
  title={Dual targeting properties of the N-terminal signal sequence of Arabidopsis thaliana THI1 protein to mitochondria and chloroplasts},
  author={Sabrina Moutinho Chabregas and Douglas Dalle Luche and Leonardo Paiva Farias and Alberto F C Ribeiro and Marie-Anne Van Sluys and C. F. M. Menck and Marcio C. Silva-Filho},
  journal={Plant Molecular Biology},
  year={2001},
  volume={46},
  pages={639-650}
}
thi1 has been recently isolated fromArabidopsis thaliana and is probably involved in both thiamine biosynthesis and as protection of organellar DNA from damage. Studies of thiamine biosynthesis in plants suggests a plastid location for the pathway, which is in agreement with the predicted THI1 N-terminal chloroplastic transit peptide (TP). On the other hand, thiamine is synthesized in mitochondria in yeast cells. Interestingly, A. thaliana thi1 cDNA complements a yeast strain disrupted for the… CONTINUE READING