Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.

@article{Watanabe2005DualTO,
  title={Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.},
  author={Mariko Watanabe and Takeo Ohsugi and Momoko Shoda and Takaomi Ishida and Shigemi Aizawa and Masae Maruyama-Nagai and Atae Utsunomiya and Shin Koga and Yasuaki Yamada and Shimeru Kamihira and Akihiko Okayama and Hiroshi Kikuchi and Kimiharu Uozumi and Kazunari Yamaguchi and Masaaki Higashihara and Kazuo Umezawa and Toshiki Watanabe and Ryouichi Horie},
  journal={Blood},
  year={2005},
  volume={106 7},
  pages={
          2462-71
        }
}
Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia (ATL), a fatal T-cell leukemia resistant to chemotherapy, after more than 50 years of clinical latency from transmission through breast-feeding. Polyclonal expansion of virus-infected T cells predisposes them to transformation. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in the leukemic cells is essential for their growth and survival. Blocking NF-kappaB has been shown to be a potential strategy to treat… CONTINUE READING

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