Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer

@inproceedings{Ma2014DualTO,
  title={Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer},
  author={Liang Ma and Fuminori Sato and Ryuta Sato and T Matsubara and Kenichi Hirai and Mutsushi Yamasaki and Toshitaka Shin and Tatsuo Shimada and Takeo Nomura and Kenichi Mori and Yasuhiro Sumino and Hiromitsu Mimata},
  booktitle={Oncology reports},
  year={2014}
}
Heat shock proteins (HSPs), which are molecular chaperones that stabilize numerous vital proteins, may be attractive targets for cancer therapy. The aim of the present study was to investigate the possible anticancer effect of single or dual targeting of HSP90 and HSP70 and the combination treatment with HSP inhibitors and chemotherapeutic agents in bladder cancer cells. The expression of HSP90 and the anticancer effect of the HSP90 inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG… CONTINUE READING

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