Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei.

@article{Charrire2006DualTO,
  title={Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei.},
  author={Fabien Charri{\`e}re and Sunna Helgad{\'o}ttir and Elke K. Horn and Dieter S{\"o}ll and Andr{\'e} Schneider},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 18},
  pages={6847-52}
}
The mitochondrion of Trypanosoma brucei does not encode any tRNAs. This deficiency is compensated for by the import of a small fraction of nearly all of its cytosolic tRNAs. Most trypanosomal aminoacyl-tRNA synthetases are encoded by single-copy genes, suggesting the use of the same enzyme in the cytosol and mitochondrion. However, the T. brucei genome contains two distinct genes for eukaryotic tryptophanyl-tRNA synthetase (TrpRS). RNA interference analysis established that both TrpRS1 and… CONTINUE READING

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