Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.

@article{Naamati2009DualTO,
  title={Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.},
  author={Adi Naamati and Neta Regev-Rudzki and Shlomi Galperin and Roland Lill and Ophry Pines},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 44},
  pages={30200-8}
}
In eukaryotes, each subcellular compartment harbors a specific group of proteins that must accomplish specific tasks. Nfs1 is a highly conserved mitochondrial cysteine desulfurase that participates in iron-sulfur cluster assembly as a sulfur donor. Previous genetic studies, in Saccharomyces cerevisiae, have suggested that this protein distributes between the mitochondria and the nucleus with biochemically undetectable amounts in the nucleus (termed "eclipsed distribution"). Here, we provide… CONTINUE READING