Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas.

@article{Gupta2012DualtargetingIO,
  title={Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas.},
  author={Pankaj Gupta and David M. Goldenberg and Edmund A. Rossi and Thomas M. Cardillo and John C. Byrd and Natarajan Muthusamy and Richard R. Furman and Chien-Hsing Chang},
  journal={Blood},
  year={2012},
  volume={119 16},
  pages={3767-78}
}
We describe the use of novel bispecific hexavalent Abs (HexAbs) to enhance anticancer immunotherapy. Two bispecific HexAbs [IgG-(Fab)(4) constructed from veltuzumab (anti-CD20 IgG) and milatuzumab (anti-CD74 IgG)] show enhanced cytotoxicity in mantle cell lymphoma (MCL) and other lymphoma/leukemia cell lines, as well as patient tumor samples, without a crosslinking Ab, compared with their parental mAb counterparts, alone or in combination. The bispecific HexAbs have different properties from… CONTINUE READING
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